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Du Z, Wu T, Liu L, Luo B, Wei C
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Oxidative stress is a major hallmark of skin aging that may lead to DNA damage, mitochondrial dysfunction, and inflammation at the cellular levelall of which contribute to aging skin

doi: 10.1016/j.ejmech.2015.04.040 132 PolizziA.SantonocitoS.Lo GiudiceA.AlibrandiA.De PasqualeR.IsolaG
This triggers the UPR, which can promote cell survival or apoptosis depending on the severity and duration of the stress

[DOI] [PMC free article] [PubMed] [Google Scholar] 81.McMichael M.A., Freeman L.M., Selhub J., Rozanski E.A., Brown D.J., Nadeau M.R., Rush J.E

doi: 10.1042/BST20190088 31 XuWWangYHouGWangJWangTQianJet al
