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This property is of special interest in studies focusing on microvascular repair, ischemia, and circulatory regulation under chemically induced injury or surgical conditions

Vitamin B12 (cobalamin) plays essential roles in neurological function, red blood cell formation, and DNA synthesis

A maintenance dose is the dose given regularly over the long term to maintain the desired effect after the initial response has been achieved

Journal of Applied Physiology , 110(3), 774-780

It typically presents as macrocytic megaloblastic anemia and neurological impairments, including sensory and motor disfunctions, predominantly in the lower extremities, ataxia, and in more advanced stages cognitive decline progressing to dementia, as well as psychiatric disturbances ( Subclinical B12 deficiency, however, is far more prevalent, affecting up to 26% of the general population