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Approach The goals of treatment of COPD are to prevent and control symptoms, to reduce the severity and number of exacerbations, to improve respiratory capacity for increased exercise tolerance, and to reduce mortality.[1] Systematic reviews report a modest reduction in rate of decline of FEV among patients receiving pharmacological therapy.[84][85] Further research is needed to find out which patients are most likely to benefit. There is a stepwise approach to therapy, and treatment should be individualised for general health status and comorbid conditions

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For testing, animals were anesthetized with ketamine (80 mg/kg) and xylazine (10 mg/kg) via i.p