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Another animal study showed that inhibition of TMAO formation can upregulate the host hepatic bile acid synthetic enzyme CYP7A1 and alter the expression of hepatic genes critical for bile acid feedback regulation, thus preventing diet-driven hepatic cholesterol accumulation (Pathak et al., 2020)

It is important to note that changes in BMAT during anorexia or caloric restriction can be transient if the disease is not treated

Nutrients 11(8) 2019 PMC6722940 Ahmad I, Zelnick LR, Batacchi Z, Robinson N, Dighe A, Manski-Nankervis JE, Furler J, O'Neal DN, Little R, Trence D, Hirsch IB, Bansal N, de Boer IH

While major regulatory bodies like the FDA and EFSA deem it safe for the general public, the IARC has classified it as "possibly carcinogenic to humans" (Group 2B)