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Pharmacol Rev 50:335356 Mastri C, Thorborn DE, Davies AJ, Ariyanayagam MR, Hunter KJ (2001) Polyamine and thiol metabolism in Trypanosoma granulosum: similarities with Trypanosoma cruzi

Programmed cell death-1 expression on macrophage membranes optimized the efficacy of immunotherapy, due to the PD-1/PD-L1 signal axis blockade

Immune function : Glutathione is important for immune function

They fall into two major classes: LonA, encoded primarily in bacterial and eukaryotic genomes, and LonB, present in archaea

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Patient-reported outcomes from the BESPOKE CRC study