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Ao incorporar uma extenso N-terminal e uma substituio especfica de aminocido, esta variante de longa durao exibe afinidade de ligao reduzida para protenas de ligao IGF (IGFBPs), que normalmente inibem a atividade do IGF-1 nativo

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Absolute bioavailability (F) after oral doses was calculated as mean of the ratio AUCp.o

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