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14 Forest plot of the progressive sperm motility in infertile patients treated with antioxidants (AOXs) compared to placebo or untreated infertile controls, after the removal of studies including patients with varicocele undergoing varicocele repair

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Panminerva Med 45(1):713 [PubMed] [Google Scholar] Halliwell B (2018) Artefacts with ascorbate and other redox-active compounds in cell culture: epigenetic modifications, and cell killing due to hydrogen peroxide generation in cell culture media

doi: 10.1096/fj.201802829R 57 OrsticaLPobleteCRomeroCVegaM

An RCT of 174 patients with severe alcoholic hepatitis found that the combination of prednisolone + NAC (IV for 5 days, then oral for 2 weeks) significantly reduced 1-month mortality compared to prednisolone alone (8% vs 24%, p=0.006), though the difference was not significant at 6 months (Nguyen-Khac et al., N Engl J Med, 2011) [36]

RonenGCohenMZamirDHirschbergJ.Regulation of carotenoid biosynthesis during tomato fruit development: expression of the gene for lycopene epsilon-cyclase is down-regulated during ripening and is elevated in the mutant delta