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Restoration of functional VHL via exogenous expression of pVHL reverted ccRCC cells to an oxidative metabolism and rendered them insensitive to the induction of ferroptosis

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Further studies have revealed that Lip-1 not only prevents mitochondrial lipid peroxidation but also restores the expression of key molecules involved in ferroptosis regulation, including GSH, GPX4 and ferroptosis suppressor protein 1 (135,136)

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