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Since metabolites are the final downstream products of transcription and translation, they are closest to the phenotype ( To date, to identify biomarkers for the diagnosis and treatment response of MDD, lipids ( By profiling the serum metabolites of the patients with MDD and the control group, metabolites showing differences between the groups were identified as potential biomarkers

Oxidative stress, along with structural changes such as axonal loss and demyelination from toxic insults like hyperglycemia and alcohol consumption, are also associated factors

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