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Both conditions involve complex pathological mechanisms that include primary mechanical damage followed by secondary injury cascades involving inflammation, oxidative stress, and regulated cell death pathways such as ferroptosis (217, 218)

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doi: 10.3389/fimmu.2020.00583 127 YasojimaKSchwabCMcGeerEGMcGeerPL

When a full blood count reveals macrocytosis (enlarged red blood cells, indicated by a raised MCV), this should prompt investigation for B12 or folate deficiency before relying on HbA1c for diabetes management decisions

Molecular pathways: the metabolic regulator estrogen-related receptor as a therapeutic target in cancer