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and the use of antivirals that enhance activation of the Nrf2 transcription factor together with N-acetylcysteine administration restore GSH levels correcting the SARS-CoV-2-mediated impaired GSH metabolism (Aquilano et al., 2014

The TSS pathway is active in the liver and brain

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1f), long-term HFD consumption significantly increased hepatic protein S -glutathionylation when compared with a control diet, as demonstrated by marked elevations in hepatic protein-SSG adducts by western blot analysis

doi: 10.3390/jcm8122128 28 UhrinPSchoferCZaujecJRybanLHilpertMWeipoltshammerKet al

Redox state and redox environment in biology