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JAMA Psychiatry 76:924

doi: 10.1080/15569543.2018.1514637

Discussion Despite several studies into the biology and genetics of hair greying or canities, the mechanism by which human scalp hairs lose pigmentation remains poorly understood, due in part to the complexity of interaction between different cell types, complex protein interactions, differential gene expression during the hair growth cycle, and variable conditions that occur within the hair follicle microenvironment 1,7,8,9,10,13,41,60,69,70,71,72,73,74

K., Blot, W

The burning of tobacco produces ROS in the gas phase inhaled by smokers, as part of the mainstream smoke (57)