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The transcription factor Nrf2, possibly in complexes with other Jun or Maf proteins, was found to be responsible for trans -activating the human GCLC promoter via binding to ARE4 in response to numerous treatments including -NF, pyrrolidine dithiocarbamate, TBH [104,105], and insulin [106]
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Database (Oxford)

Your bodys glutathione levels can be quickly drained by environmental stressors, poor diet, and alcohol
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As a result lower energy levels and frequent inflammation often occur which opens the door to diseases and accelerates the ageing process