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Thiamine deficiency reduces the activity of thiamine-dependent enzymes, notably -ketoglutarate dehydrogenase complex, resulting in mitochondrial dysfunction, which leads to reduced activity of the tricarboxylic acid cycle in endothelial cells, astrocytes, and microglia

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This is why supporting the bodys natural fat-to-energy process is helpful

4-en-VPA and propionic acid metabolites resulting from -oxidation could also promote hyperammonaemia [19,24]
