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When submitting the application, companies also must submit data collected during preclinical and clinical studies of the investigational new drug (IND)

Murphy CT, Hu PJ (2013) Insulin/insulin-like growth factor signaling in C

In contrast to earlier GLP-1 receptor agonists, which primarily target appetite suppression and glycemic improvement, GLP-3 leverages GCG receptor activation to stimulate lipolysis and elevate basal metabolic rate, thereby contributing to a more pronounced and sustained reduction in adiposity as observed in research models

doi: 10.1016/j.jnutbio.2005.03.027