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Modelos animales (escalamiento) : - Rata: 50200 g/kg semanal

Long-Term Treatment with Antioxidants and a Program of Behavioral Enrichment Reduces Age-Dependent Impairment in Discrimination and Reversal Learning in Beagle Dogs

DOSAGE GUIDE AND PREPARATION: Doses in relation to body weight are: Estimating Potential for Hepatotoxicity The following nomogram has been developed to estimate the probability that plasma levels in relation to intervals post ingestion will result in hepatotoxicity

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Asselin, E., Mills, G

Expert Rev Proteom 15:113130 Tan Q, Li J, Yin HW, Wang LH, Tang WC, Zhao F, Liu XM, Zeng HH (2010) Augmented antitumor effects of combination therapy of cisplatin with ethaselen as a novel thioredoxin reductase inhibitor on human A549 cell in vivo