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With iron-chelating properties and monoamine oxidase inhibitory activity, VK-28 derivatives (including M30, M32, and HLA20) target multiple neurodegenerative pathwaysthey suppress oxidative stress-related pathways (e.g., Keap1-Nrf2), modulate the AKT/mTOR pathway, and alleviate -syn aggregation (230)

Consequently, FIN56 inhibits Sec integration into the catalytic subunit of GPX4, reducing its antioxidant capacity ( 4.2 Non-enzymatic pathway of ferroptosis 4.2.1 Iron homeostasis Iron is crucial for living organisms, and its deficiency can cause health issues

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In some cases, we add an activator like calcium chloride to trigger the immediate release of growth factors