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Ketogenic and low-carbohydrate diets greatly increase reliance on fat oxidation [7889], which would logically be expected to increase mitochondrial respiration and mtROS production and, in turn, induce mitohormesis
Al Bostami, R
In bypass therapies, analogs of 4-HB are used as alternate ring precursors that function to bypass a blocked step in the CoQ biosynthetic pathway
We note that the Lin et al., 2022 HRQL study [83] was a secondary exploratory analysis and that primary or secondary endpoints were not reported
Naumenko V, Turk M, Jenne CN, Kim S-J (2018) Neutrophils in viral infection

Converting tanshinone IIA into its sodium sulfonate form (sodium tanshinone IIA sulfonate, STS) greatly increases polarity and bioavailability, and indeed STS is used interchangeably with tanshinone IIA in studies and has been approved in China as an injectable drug (Shao et al., 2024
