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Heianza Y, Ma W, Manson JE, Rexrode KM, Qi L

Botulinum toxin type A (BTX), which is considered as a thirdline treatment for NP, inhibits pain progression by suppressing the release of neurotransmitters and neuropeptides like glutamate, substance P, and calcitonin gene-related peptide [74]

*Correspondence: Mohamed Ashraf Virmani, [email protected] Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

References 1.Atkins D, Best D, Briss PA, Eccles M, Falck-Ytter Y, Flottorp S, Guyatt GH, Harbour RT, Haugh MC, Henry D, Hill S, Jaeschke R, Leng G, Liberati A, Magrini N, Mason J, Middleton P, Mrukowicz J, OConnell D, Oxman AD, Phillips B, Schunemann HJ, Edejer T, Varonen H, Vist GE, Williams JW, Jr, Zaza S

However acetyl-L-carnitine was not found to benefit young men suffering Down's Syndrome [117]

Topiramate is a sulfa-based antiepileptic medication known to confer a risk for AACG