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In pristane-induced lupus, Lactobacillus strains reduce Th17 frequency by inhibiting IL-1/NLRP3 inflammasome signaling and upregulating TGF-/Smad3 to expand Tregs (120)
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Another mechanism would be an elevation in endogenous diacylglycerol (DAG) levels which can activate tyrosine kinase-inducing melanogenesis (Videira et al., 2013)
Potential side effects may include mild gastrointestinal discomfort, headache, or allergic reactions
Use In-vitro laboratory research only Batch documentation panel COA status: available on request through VEXA support
Cells were left untreated ( A , C ) or treated with CHIR99021 ( B , D )
