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10.1186/s11658-020-00205-0 65

The animals were kept under standard conditions

This response was significantly different from the background response which was obtained by applying Glu in the presence of glutamate receptor blockers, namely, AP5 25 M, a broad-spectrum NMDAr antagonist, DNQX 10 M, a non-NMDA receptor antagonist, and MPEP 10 M, a type 5 metabotropic glutamate receptor antagonist

However, the direct effect of NSAIDs on gastric and intestinal mucosal cells is as a result of inhibitory effects of NSAIDs on constitutive cyclooxygenase in the gastrointestinal cells [38]

The expression levels of the FNSII genes were consistent with flavone accumulation patterns in flower buds

There is also a very safe profile (lethal dose (LD1) could be not achieved) [84], a point recently confirmed in a large study conducted by Xu and collaborators [85]