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It really depends on how your body uses the NAD+ and what your lifestyle demands are
As GSTP1 appears not to be expressed in HepG2 cells ( Table 1 Specific activity of GST in HepG2 cells transfected with empty vector and human GSTP1 gene

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Notwithstanding the age related relevance of the cellular defense mechanisms, the pleiotropic and redundant array of protective enzyme systems that counteract ROS include many that utilize GSH directly

2007;178(4):439-449 Hedberg A

Within the substantia nigra (largest of four nuclei in the basal ganglia of the midbrain), and some other regions of the brain, synthesis proceeds only to dopamine
