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91 Oral administrated NAM is converted into NA in the small intestine and colon by nicotinamidase PncA of gut microbiota

One potential explanation for the significantly increased chimerism of the secondary transplants of the young Mda5 -/- is the increase in the frequency of the LSKs and HSCs in the primary transplant (not significant due to the transplanted animals with very low chimerism)

The minimum required sample size was determined using the formula for comparing two independent means (unpaired t-test): where for a 95% confidence level, for 80% statistical power, represents the pooled standard deviation, and is the expected difference in mean oxidative-stress parameters between groups

TMS dataset Patients The participants were recruited at HPPH from 29 May 2023 to 28 April 2024

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