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Description
Previous studies have demonstrated that BBR readily crosses the bloodbrain barrier, exhibiting rapid accumulation in the hippocampus following intravenous administration, with subsequent slow clearance (Wang et al., 2005)

The universal nature, unequal distribution and antioxidant functions of melatonin and its derivatives

J Am Geriatr Soc 2008
ISSN 0001-8244

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HMGB1 mediates synaptic loss and cognitive impairment in an animal model of sepsis-associated encephalopathy
