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HL, TJ, TY, MT and YY conceived and wrote this review

The transcriptional activity of YAP through Hippo pathway is regulated by upstream kinases MST1/2 and large tumor suppressor kinases 1/2 (LATS1/2), then the phosphorylation of YAP Serine 127 (Ser127) by LATS1/2 leads to its retention in the cytoplasm and is targeted for proteasomal degradation 24

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[DOI] [PMC free article] [PubMed] [Google Scholar] 94.Del Ro C, Navarrete C, Collado JA, et al

In other words, we know that brain bioenergetics is critical for brain function, but we still poorly understand whether astrocytes, neurons, and other cell types belonging to specific brain areas possess regional and/or local metabolic capacities and adaptations