chac1 glutathione Identification of Juglone, a 'first-in-class' inhibitor of the human degrading enzyme, ChaC1, using yeast-based high throughput screens A scheme of the mechanism
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10.1016/S0140-6736(79)92507-8 79

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Moving up faster is the single most common cause of avoidable nausea and dropout in the trial data
Peters EM, Liotiri S, Bodo E, Hagen E, Biro T, Arck PC

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