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The neuroprotective effects of carnitine have revealed its potential therapeutic value in the treatment of neurological diseases such as autism spectrum disorder, depression, and Alzheimers disease [96, 97]

The discussion regarding TMAO as a cardiometabolic risk marker is still ongoing

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they share the common properties of increasing brain glutamate concentration and neurotransmission and of activating rCMRglc in frontal areas and subcortical aminergic nuclei (Toth et al., 1993

A useful disease biomarker is typically characterized by high sensitivity and specificity, ease of collection and measurement, broad applicability, non-invasiveness or minimal invasiveness, and its ability to indicate key pathological features of the disease [26, 27]