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Incubation of human and rat liver S9 fractions with NADPH produced M3 but not M5 or M6, whereas the addition of SAM resulted in the clear formation of M5 and M6 (Supplementary Fig

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Quercetin and ellagic acid are found in many fruits and vegetables, while curcumin is mostly from turmeric roots ( Curcuma longa L.)

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We propose that differences in the GSH binding mode compared to that of GRXC2 are responsible for the lack of enzymatic activity

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