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The difference between DA vs MDA is reflected in the regulations, Practical Test Standards (PTS, soon Airman Certification Standards) and TERPS

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You need a disciplined set of indicators: AE rate per participant-month (overall and by site) SAE timeliness distribution (not just % on time, but how late and why) Protocol deviation clusters (category + site + recurrence) Query patterns in safety fields (suggesting confusion or under-capture) Lab abnormal trends (outliers and repeated borderline signals) Because data capture quality drives signal detection, you need CRF alignment (CRF best practices) and basic analytic literacy (biostatistics overview)

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