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Activated caspase-8 can trigger apoptosis either directly by proteolytically activating the downstream effector caspases, caspases-3, (-6) and -7, however can also proteolytically activate the BH3-only protein BID, thereby increasing effector caspase activation by engaging the intrinsic apoptotic pathway (see above) [10]

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At our clinic in Doral, FL, we work almost exclusively in the superficial to light-medium range for acne, which is where the clinical benefit is real and the risk of post-inflammatory hyperpigmentation is manageable

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