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Consistent data were obtained by Truttmann and colleagues for orthologs of GRP78 (HSP3 and HSP4) and FIC (FIC-1) in Caenorhabditis elegans (Truttmann et al., 2016)

Theyre also approved for helping to treat serious wounds from trauma or burns

(115) reported that chronic Ang II infusion causes migration and accumulation of macrophages in the renal interstitium, triggering the mechanism of renal fibrosis

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This, in turn, could either lead to supplementation in the event of deficient endogenous Wnt signaling with the supplemental Wnts doubling as agonists or prompt the restoration of Wnt signaling if the endogenous function is completely absent (which could be investigated in knockout models)