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Our meta-analysis showed that the overall effect size of N -acetylcysteine was moderate (SMD = 0.77) and comparable with the antidepressant effect sizes of aripiprazole (SMD = 1.35), haloperidol (SMD = 0.82), and risperidone (SMD = 0.59), as indicated by a previous meta-analysis [56]

10.1111/j.1365-313X.2004.02153.x 64 Gonzlez-BallesterD.CamargoA.FernndezE

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Furthermore, glutamine can change the composition or function of microbiota [78] by potentially influencing gut microbial metabolism, including the production of the metabolites from the tumor-promoting/suppressing gut microbiome, metabolites that contribute to extracellular acidosis, and short-chain fatty acids (SCFAs) that provide energy to colonic epithelial cells [85,86,87,88]

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Wu Y, Gong P