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American Journal of Health-System Pharmacy, 61 (18), 192838

But it may not hold that title for long

Ziyad Al-Aly, a clinical epidemiologist at WashU Medicine and Chief of Research and Development Service at the VA Saint Louis Health Care System

Neither approach helps you make an actual decision

Multiple cardiovascular outcomes trials (CVOTs) have shown significant reductions in major adverse cardiovascular events (MACE), which typically includes cardiovascular death, non-fatal myocardial infarction, and non-fatal stroke

It is not as powerful for weight loss as GLP-1 medications, so patients should not expect dramatic results from metformin alone