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Due to its unique biochemical function of directly reducing lipid peroxides and blocking the oxidative chain reaction on cell membranes, GPX4 is often regarded as the central barrier or gatekeeping enzyme in the ferroptosis response

In that pathological model, plasma homocysteine accumulation was mainly attributed to increased homocysteine production from methionine but not impaired homocysteine conversion to cysteine

434,435 Notably, indole-3-carbinol effectively prevents rotenone-induced -synuclein accumulation, astrocytic activation, neuroinflammation, and motor dysfunction by activating the SIRT1/AMP-activated protein kinase (AMPK) signaling pathway

demonstrated that cardiac glycosides promoted autophagy through AMPK and ERK1/2 activation, inducing tumor suppression in NSCLC cells (Wang et al

AA: Supervision, Data curation, Writing original draft

We conducted an initial review via Google Scholar and PubMed and screened the available titles and abstracts