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To view digital features for this article go to Introduction Obesity (defined as a body mass index [BMI] 30 kg/m 2 in adults [1]) is a major health concern in the USA [2] and is associated with multiple complications, including cardiovascular disease, type 2 diabetes, and osteoarthritis [3,4,5,6,7,8]

The theoretical advantage is significant

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-arrestins were first recognized for desensitizing GPCRs by uncoupling them from G-proteins and promoting receptor internalization via clathrin-coated pits, but are now known to act as signaling scaffolds themselves, initiating distinct pathways like ERK, JNK, or NF-B activation

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