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If a vial has been stored for longer than the recommended shelf life, degradation has almost certainly occurred even if the solution looks perfect

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doi: 10.1016/j.nbd.2017.04.004

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The application of NaBPC157 leads to significantly reduced pathomorphological findings of antracyclin cardiomyopathy (severe damage of myocytes and vessel walls, and vacuolisation) after single, and in greater extent, after multiple doxorubicin administration