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The genes for mitobiogenesis and mitophagy were downregulated when both Mfn1 and Mfn2 were removed in midgestational and postnatal cardiac myocytes, and the mice went on to develop cardiomyopathy and died within 16 days of birth [244]

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A variety of cellular stresses, including DNA damage can cause the induction of cellular senescence, which represents a multifaceted and highly heterogeneous cellular state characterized by irreversible growth arrest and importantly the secretion of a multitude of factors, including proteases and chemokines 2

In normoxia, the UV-vis spectra of the probe DSNBD-GSH (10 M) exhibited two peaks at 300 nm and 360 nm, while the incubation with GSH (1 mM) caused the decrease of the peak at 360 nm (Supplementary Figure S7A)

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