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Some strategies, such as agonist HGF monoclonal antibodies, HGF gene transfer therapy, and HGF mimetics, may overcome the pharmacokinetic limitations

doi: 10.1186/1746-1596-5-79 66 WuGLiuJWuZWuXYaoX

Immune checkpoint inhibitors targeting PD-1/PD-L1 have transformed cancer therapy, but issues like poor oral availability, side effects, and high cost make small-molecule alternatives appealing

Ann Neurol 79: 387403, 2016
