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Induced fit mechanisms can be more clearly thought of in the context of standard free energy surface diagrams used in Figure 1, which can incorporate both kinetic and equilibrium aspects of the protein networks involved in terms of the barrier heights between different interconverting protein states

For example, the nanoparticle drug PAP-SeNPs constructed from SeNPs and red mushroom polysaccharide component (PAP-1a) can significantly activate the Tlr4/Myd88/NF-B pathway, polarizing M2 macrophages into M1 macrophages thereby activating anti-tumor immune responses (237)

Because NNMT is involved in basic metabolic processes, 5-Amino-1MQ is often used as a research tool to reduce NNMT activity in controlled experimental systems

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