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Given that numbers of inflammation-related diseases, such as rheumatoid arthritis, are associated with the downregulation of antioxidases 3,4 , while the direct administration of these natural antioxidases in pathological sites suffers from their over-large sizes leading to short circulating half-life, limited cell permeability, and antigenicity 5

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A., Schultz, C

Our results, however, further emphasized that ENPP2 is not only a target of exosomal miR-29c-3p but also controlled specifically by M1 macrophages, and not by M2 macrophages

[DOI] [PMC free article] [PubMed] [Google Scholar] 681.Hertz L

Topical application does not typically cause systemic side effects