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Copper (Cupric Chloride) for Injection is an injectable form of copper used primarily as a trace element supplement in total parenteral nutrition (TPN) to prevent and treat copper deficiency in patients who are unable to receive adequate nutrition orally

In this study, we reveal a cysteine-reactive covalent ligand EN25 that covalently targets an allosteric cysteine C114 on GCLM, the modifier subunit of GCL, leading to inhibition of GCL activity, lowering of cellular GSH levels, and impaired cell viability in ARID1A-deficient cancer cells that are particularly vulnerable to glutathione depletion, but not in ARID1A-positive cancer cells

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Other promising botanical compounds and their molecular targets and mechanisms of action with regard to potential protection against SCI were also described

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