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The dose of vitamin B12 used in the VISP and NORVIT trials and issues with the design of the VISP trial might have obscured a small but still meaningful benefit to vitamin B12 supplementation (234)

Endocrinology 142 : 51825189 Hollenga C et al

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Rather than destroying blood vessels, researchers could potentially develop drugs that interfere with fatty acid uptake into fat tissue, reducing fat accumulation without the dramatic tissue destruction

These findings suggest that NNMT inhibition may modulate the metabolic responses to physical activity by altering cellular energy metabolism across multiple tissue types