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When UA is activated by TLR4, its downstream signaling cascade (such as the IKK/IB/NF-B pathway) will be released, ultimately leading to induction of pro-inflammatory cytokines/mediators and tissue damage (Zhou et al., 2012)

Epithalon is a synthetic tetrapeptide used in experimental models to study peptide-cell interactions, intracellular signaling pathways, and biochemical processes under controlled laboratory conditions

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Neutrophils The role of neutrophils throughout the inflammatory response involves activation, migration, and clearance of pathogens and damaged tissues

25 However, the stage of development for these biomarkers and how they will be integrated into clinical strategy remain unclear

These differences in expression patterns may help identifying the function of the three AtGSTL genes