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While radiotherapies primarily leverage radical-mediated killing (dependent on oxygen and iron), agents like pharmacologic ascorbate largely utilize diffusible non-radicals for programmable selectivity

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The identified mechanism involved down-regulation of the PI3K/Akt-GSK3-FBW7 signaling axis, which promoted the destabilization of c-Myc, required for a xanthohumol-induced decrease in HK2 [133]

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