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Because r is built from population-average TBW, it assumes a normally hydrated person

These results indicated that GHK decreases AQP4 expression via miR-146a-3p through the PI3K/Akt pathway (Figure 7)

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Importantly, microglia in this activated state also secrete pro-inflammatory cytokines such as TNF-, IL-1, and IL-6, which further amplify ROS production and reinforce the inflammatory state
