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Evidence Gap : Most studies are small-scale, and larger trials are needed to confirm efficacy

Based on preclinical (animal and cellular) data only, inhibition of NNMT by 5-Amino-1MQ is theorised to: Raise intracellular NAD+ levels Activate SIRT1 and other sirtuins (proteins linked to metabolic regulation) Reduce fat cell (adipocyte) size and proliferation Improve insulin sensitivity These effects have been demonstrated in mouse models (Neelakantan et al., 2019), but robust human clinical trial data are currently absent

It is important to have blood work performed prior to beginning this medication to assess liver and kidney function as well as assist in identifying any additional underlying health conditions

Avocado, olive oil, fatty fish, and nuts provide excellent options that also support hormone production and cellular function

Inspect the solution: if it is discolored or contains particulate matter that does not dissolve, do not use it

An arm entry was made when an animal crossed one-third of the arm length from the central platform