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Elliot JG, Donovan GM, Wang KCW, Green FHY, James AL, Noble PB
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Symptoms typically occur within 1 month of initiating treatment with topiramate but may occur at any time during therapy

Biomed Pharmacother 120:109526 Ye Y, Bajaj M, Yang H-C, Perez-Polo JR, Birnbaum Y (2017) SGLT-2 inhibition with dapagliflozin reduces the activation of the Nlrp3/ASC inflammasome and attenuates the development of diabetic cardiomyopathy in mice with type 2 diabetes

The 4mg arm discontinuations were fromdeathand cancer