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282,283 While Met790 oxidation is reversible, Cys797 oxidation on EGFR T790M further upregulates EGFR-NOX2, which increases ROS production, resulting in aberrant EGFR expression
[DOI] [PMC free article] [PubMed] [Google Scholar] 126.Valle J.W., Vogel A., Denlinger C.S., He A.R., Bai L., Orlova R., Cutsem E.V., Adeva J., Chen L., Obermannova R., et al
