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The lysate was then centrifuged at 12,000 g for 10 min at 4 C, and the resulting supernatant was used as the sample for testing

Yes, you can absolutely use both ingredients to target different layers of skin aging

H.ChenT.et al (2002)

NPJ Biofilms Microbiomes 11:27

Thus, while subcritical water extraction is promising and eco-friendly, its limitations in compound stability, selectivity, and process complexity require careful management to maximize polyphenol recovery and bioactivity (66)

Your doctor says it's normal, maybe even gives you a reassuring nod
