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Additionally, GLP-1R agonists inhibit tau protein hyperphosphorylation, promote the release of brain-derived neurotrophic factor, and reduce neuroinflammatory responses by inhibiting microglial and astrocyte activation [55,56,57]

Acknowledgments We thank Lauren Hayashi for assistance with experiments and Chris Riso for fish husbandry support

RNA-seq and RNA-seq analysis were performed by Bioprofile Technology Company Ltd (Shanghai, China)